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Tue, Apr 05

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Webinar

Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing

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Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing
Investigating antimicrobial mechanisms-of-action using automated genome-wide and gene-specific editing

Time & Location

Apr 05, 2022, 5:00 PM CDT

Webinar

About the event

Some heterologous metabolic pathway intermediates can inhibit microbial growth and stifle production capabilities of bioindustrial strains through poorly understood mechanisms. We have developed a novel approach to investigating the mechanisms of action of small inhibitory molecules using automated, trackable genome engineering. A combination of genome-wide and gene-specific edits allowed us to identify genes and individual residues implicated in biological responses to p-coumaric acid and resveratrol and provided target leads for engineering tolerance or enhanced sensitivity to these compounds.

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