top of page

Tue, Apr 26

|

Webinar

Modelling of cellular interactions in mixed murine organoids

Learning Objectives: - Identify generation of mixed murine organoids and enteroid monolayers - Discuss the use of (time-lapse) microscopy to follow cellular behavior - Discover insight in the role of cell competition in tumor growth

Tickets are not on sale
See other events
Modelling of cellular interactions in mixed murine organoids
Modelling of cellular interactions in mixed murine organoids

Time & Location

Apr 26, 2022, 7:00 AM PDT

Webinar

About the event

Cell competition is a mechanism of interaction that dictates cell selection based on differences in cellular fitness. We developed a model of mixed murine organoids and enteroid monolayers to study such complex cellular interactions in a mammalian system. We combined this model with (time-lapse) microscopy and transcriptome analysis to show that cell competition drives growth of cancer cells by active out-competition of wild-type cells through forced cell death and cell-state change in a JNK-dependent manner.

Share this event

bottom of page